Research ArticleA high-corn-oil diet strongly stimulates mammary carcinogenesis, while a high-extra-virgin-olive-oil diet has a weak effect, through changes in metabolism, immune system function and proliferation/apoptosis pathways☆,☆☆
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Abbreviations
DMBA
7,12-dimethylbenz(a)anthracene
EVOO
extra-virgin olive oil
FA
fatty acids
GO
gene ontology
HCO
high corn oil
HOO
high extra-virgin olive oil
LF
low fat
MUFA
monounsaturated fatty acids
PUFA
polyunsaturated fatty acids
Keywords
Dietary lipids
Breast cancer
Olive oil
Transcriptome
Immune system
Apoptosis
Metabolism
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Funding: This work was supported by grants from “Plan Nacional de I+D+I” (AGL2006-07691); “Fundación Patrimonio Comunal Olivarero (FPCO)” (FPCO2008-165.396; FPCO2013-CF611.084); “Agencia para el Aceite de Oliva del Ministerio de Agricultura, Alimentación y Medio Ambiente” (AAO2008-165.471); “Organización Interprofesional del Aceite de Oliva Español (OIAOE)” (OIP2009-CD165.646), “Departaments de Salut i d'Agricultura, Alimentació i Acció Rural de la Generalitat de Catalunya” (GC2010-165.000), FPCO and OIAOE (FPCO-OIP2016-CF614.087).
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Author disclosures: no conflicts of interest.
© 2018 The Authors. Published by Elsevier Inc.